巴西专利BR112012006614B1 non-therapeutic method to disinfect a surface, antimicrobial compositions, non-therapeutic uses of a

专利PDF首页>>巴西专利

专利附录

专利说明

权利要求

类似技术

同族专利

引用文献

法律状态

优先权

专利摘要:
METHOD FOR DISINFECTING A SURFACE, ANTIMICROBIAL COMPOSITIONS AND USES OF A COMPOSITION. The present invention relates to the method for disinfecting a surface and the antimicrobial composition particularly for personal hygiene, oral care, or rigid surface cleaning. It is an object of the present invention to provide an antimicrobial composition that has relatively rapid antimicrobial action. The inventors concluded that the use of small amounts of eugenol in combination with thymol and terpineol allows for this rapid kinetics in much smaller amounts of detimol and terpineol than without eugenol.
公开号:BR112012006614B1
申请号:R112012006614-5
申请日:2010-09-03
公开日:2021-02-17
发明作者:Srilaxmi Venkata Medepalli；Amit Chakrabortty；Bharat Cheviti
申请人:Unilever Nv；
IPC主号:

专利说明:

[0001] [001] The present invention relates to a method for disinfecting a surface and an antimicrobial composition. It refers, in particular, to an antimicrobial composition for personal hygiene, oral care or cleaning of rigid surfaces. BACKGROUND OF THE INVENTION
[0002] [002] Soap compositions for sanitization and disinfection that include chlorine-based antimicrobial agents, such as triclosan, are known. Such compositions require a very long contact time to provide an effective antimicrobial action. In practice, users, in particular, children, do not consume much time in cleaning and, as a result, cleaning with such compositions does not provide adequate prevention of topical or superficial infection or adequate protection against disease. The user, despite cleaning his hands, probably has a relatively inadequate removal of bacteria and can cause additional contamination of animated and / or inanimate surfaces and lead to the spread of pathogens and consequent diseases. Users in general, and children in particular, who wash contaminated hands before meals with slow-acting antimicrobials, for a relatively short time are at risk for disease. In addition, many microbial action agents, in addition to abrasives, are included in oral care compositions such as toothpaste, but such assets generally require many minutes, if not hours, before the effective antimicrobial action is carried out. People often brush their teeth or clean their mouths for a very short period of time, for example, on the order of 1 minute or less, making such compositions quite ineffective in offering the desired benefit. Likewise, when it comes to cleaning hard surfaces, for example cleaning floors, table tops or utensils, the antimicrobial in the compositions is in contact with the substrate for a few minutes, after which the surface is also scrubbed or washed with. Water. These short scales of cleaning action time are ineffective in providing the desired benefit, since the most well-known antimicrobials, normally used in such products, take many hours to provide the desired extermination of microbes.
[0003] [003] Therefore, there is a need to provide a composition that gives a relatively more effective antimicrobial action when the cleaning period is relatively short, typically about 5 minutes or less, preferably less than 2 minutes and, in many cases, less a minute or, in some cases, dropping to 15 seconds or less.
[0004] [004] The present applicants, in the document WO10046238, found, surprisingly, that compositions that comprise selected ingredients, that is, thymol and terpineol, in selective concentrations offer a relatively fast antimicrobial action. They continued their research to find more effective combinations of assets that not only offer the desired rapid antimicrobial action, but are capable of offering it in lower concentrations. Surprisingly, it was found that the use of very small amounts of eugenol, combined with thymol and terpineol, allows for rapid kinetics in a much smaller amount of thymol and terpineol than without eugenol.
[0005] [005] Eugenol, terpineol and thymol are all components of essential oils and have been cited together with a host of other such essential oil components in previous publications.
[0006] [006] JP2196718 (Kowa, 1989) discloses a liquid for external use that has increased solubility and stability, containing 0.1 to 5% indomethacin and a 0.3 to 10% auxiliary dissolution as essential components, auxiliary solution selected from limonene, pipene, camphene, cymene, citronelol, geraniol, nerol, linalool, terpineol, rhodinol, borneol, isoborneol, menthol, camphor, thymol, safrole, isossafrol, eugenol and isoeugenol.
[0007] [007] JP19960080819 (Kowa, 1996) discloses the composition for the oral cavity, which contains the following components (a) and (b) in addition to the components (c) - (e), (a) capsules containing 0, 1 to 20% by weight of agar as a substance to form a wrap and which has an average particle size of 0.3 to 3 mm, (b) 0.0001 to 1% of more than one type of perfume selected from of linalool, eugenol, anethole, terpineol, thymol, camphor, cinnamic alcohol, cinnamic aldehyde and cineole, (c) 0.1 to 1% menthol, (d) a surfactant ion, and (e) an abrasive.
[0008] [008] The document US6613728 (P & G, 2003) discloses the method of providing long-term disinfection for a rigid surface, the said method comprises a step containing the rigid surface said with a liquid disinfectant solution that has a pH of 2 to 6 and has low volatility, in which the said liquid disinfectant solution, which comprises a peroxygen bleach and an active antimicrobial selected from the group consisting of thymol, eugenol, menthol, geraniol, vertenone, eucalyptol, pinocarveol, cedrol, anethole , carvacrol, hinoquitiol, berberina, ferulic acid, cinnamic acid, methyl salicylic acid, methyl salicylate, terpineol, limonene and mixtures thereof, and an antimicrobial compound that has a vapor pressure of less than 0.1 mmHg when measured at 20 ° C, in which the said antimicrobial compound is selected from the group consisting of citric acid, benzoic acid, benzophenone, and mixtures thereof.
[0009] [009] WO2006 / 053458 (Givaudan SA) discloses bactericidal formulas that come into contact with the human body, particularly washing formulations that include liquid soaps that comprise active perfume ingredients against gran-negative bacteria.
[0010] [010] None of the publications cited above teaches that a small amount of eugenol, when used together with a specific amount of a combination of thymol and terpineol, provides a synergistic, fast-acting antimicrobial action.
[0011] [011] It is an objective of the present invention to overcome or improve at least one of the disadvantages of the prior art, or to provide a useful alternative.
[0012] [012] Another objective of the present invention is to provide an antimicrobial composition that has a relatively rapid antimicrobial action. BRIEF DESCRIPTION OF THE INVENTION
[0013] (a) 0,005 a 5% em peso de eugenol; (b) 0,01 a 5% em peso de terpineol; (c) 0,01 a 5% em peso de timol; e (d) um veículo; a uma superfície; e (ii) lavar a superfície com um solvente adequado ou enxugar a superfície com um lenço adequado.[013] In accordance with an aspect of the present invention, a method is provided for disinfecting a surface comprising the steps of: (i) applying a composition that comprises: (a) 0.005 to 5% by weight of eugenol; (b) 0.01 to 5% by weight of terpineol; (c) 0.01 to 5% by weight of thymol; and (d) a vehicle; to a surface; and (ii) wash the surface with a suitable solvent or wipe the surface with a suitable tissue.
[0014] (a) 0,005 a 5% em peso de eugenol; (b) 0,01 a 5% em peso de terpineol; (c) 0,01 a 5% em peso de timol; e (d) 1 a 80% em peso de um tensoativo aniônico; e (e) um veículo; [014] In accordance with another aspect of the present invention, an antimicrobial composition is provided which comprises: (a) 0.005 to 5% by weight of eugenol; (b) 0.01 to 5% by weight of terpineol; (c) 0.01 to 5% by weight of thymol; and (d) 1 to 80% by weight of an anionic surfactant; and (e) a vehicle;
[0015] [015] These and other aspects, characteristics and advantages will become apparent to those skilled in the art from a reading of the detailed description and the attached claims below. For the avoidance of doubt, any feature of one aspect of the present invention can be used in any other aspect of the invention. The term "that comprises" is intended to be understood as "that includes" But not necessarily "consists of" or "composed of." In other words, the steps or options listed need not be exhaustive. Note that the examples given in the description below are intended to clarify the invention and not to limit it to them. Likewise, all percentages are weight / weight percentages, unless otherwise stated. Except for exemplary operations and comparative examples, or where otherwise explicitly indicated, all numbers in this description indicate quantities of material or reaction conditions, physical properties of materials and / or use are to be understood to be understood as modified by the term " about".
[0016] [016] Unless otherwise specified, numerical ranges expressed in the "from x to y" format are understood to include x and y. When for a specific characteristic for several preferential bands they are described in the format "from x to y", it is understood that all those bands that combine the different end points are also contemplated.
[0017] [017] The antimicrobial composition comprises eugenol, thymol, terpineol and a vehicle. Several components of the antimicrobial composition are described below. The compositions of the present invention are preferred for non-therapeutic use and, more particularly, preferred for use in cleaning surfaces of the human body including skin, hair or oral cavity or for rigid surface cleaning applications. EUGENOL
[0018] [018] Eugenol is a guaiacol with a substituted ally chain. In general, it is extracted from certain species such as cloves or cinnamon. Eugenol has been used as a perfume component, in flavors prepared as an antiseptic or as a local anesthetic. The antimicrobial composition comprises 0.005 to 5%, preferably 0.02 to 1%, more preferably, 0.03 to 0.4%, by weight of eugenol. The composition of the invention is used in such a way that, with dilution or otherwise, eugenol is in contact with the substrate at a concentration in which it is greater than 0.01 and less than 0.2% by weight of the composition. Without intending to stick to the theory, it is believed that, while the synergistic mixture of thymol and terpineol acts as an antimicrobial agent to prevent the cellular function of targeted microbes, eugenol acts synergistically as an efflux pump inhibitor on microbial cells at very low concentrations to increase the effectiveness of the terpineol-thymol mixture, thereby ensuring antimicrobial action at low concentrations of terpineol and thymol when compared to the terpineol-thymol mixture without the use of eugenol.
[0019] [019] Eugenol has the structure:
[0020] [020] The antimicrobial composition comprises 0.005 to 5%, preferably 0.02 to 1%, more preferably, 0.03 to 0.4%, by weight of thymol. The composition of the invention is used in such a way that, with dilution or otherwise, the thymol is in contact with the substrate at a concentration that is greater than 0.01 and less than 0.3% by weight of the composition. Thymol can be added to the antimicrobial composition in purified form.
[0021] [021] Alternatively, thymus oil or thymus extract, which comprises thymol, can be added to the antimicrobial composition, while ensuring that thymol is present in the desired concentration in the composition of the present invention. Thymus oil or thymus extract are obtained from the thymus plant. The thymus plant refers to the plant that belongs to the genus Thimus and includes, but is not limited to, the following species: Thymus vulgaris, Thymus zygis, Thymus satureoides, Thymus mastichina, Thymus broussonetti, Thymus maroccanus, Thymus pallidus, Thymus algeriensis, Thymus algeriensis serpyllum, Thymus pulegoide, and Thymus ci triodorus.
[0022] [022] The structure of the thymol is given below:
[0023] [023] The antimicrobial composition comprises 0.01 to 5%, by weight of terpiol, preferably 0.05 to 5%, more preferably, 0.06 to 1%, by weight of terpineol. The composition of the invention is used in such a way that , with dilution or otherwise, the terpiol is in contact with the substrate at a concentration that is greater than 0.05 and less than 0.3% by weight of the composition. Terpineol is preferably selected from alpha-terpineol, betaterpineol, gamma-terpineol or mixtures thereof. It is particularly preferred that the terpineol is alpha-terpineol. Terpineol can be added to the antimicrobial composition in purified form.
[0024] [024] As an alternative, pine oil comprising terpineol can be added to the antimicrobial composition while ensuring that terpineol is present in the desired concentration in the composition of the present invention.
[0025] [025] The structure of a terpineol compound is given below:
[0026] [026] An advantage of including eugenol in the terpineol-thymol mixture is that, although WO2006 / 053458 lists a large number of perfume compounds that provide rapid bactericidal action when used individually, the present inventors have found that many of these compounds perfume do not provide synergistic action when used in combination as binary mixtures or ternary mixtures. This action was verified in the present invention. Another advantage of the present invention is that, with the inclusion of eugenol, the concentration of thymol and terpineol could be reduced by about an order of magnitude to obtain the same rapid antimicrobial action compared to the activity obtained with thymol and terpineol alone (without the use of eugenol).
[0027] [027] In areas such as therapeutic applications, pesticides or herbicides, sensory aspects are not fundamental. Unlike these areas, in the present invention, which is preferably personal hygiene, oral care, or rigid surface cleaning compositions, the low bands Preferred concentrations of terpineol, thymol and eugenol are important since the product is in contact with hands, mouth or other parts of the body, in which sensory aspects such as smell and skin sensation are fundamental for consumer acceptance. VEHICLE
[0028] [028] The antimicrobial composition comprises a vehicle. The vehicle can be selected from the group consisting of water, oil, solvent, inorganic particulate material, starch, polymer or mixtures thereof. Most preferably, the vehicles are water, oil, inorganic particulate material, or polymer. An even more preferred vehicle is water. The vehicle is preferably from 0.1 to 99% by weight of the composition. The antimicrobial composition can be in the form of a solid, liquid, gel, paste or soft solid and the vehicle can be selected by a person skilled in the art depending on the shape of the antimicrobial composition.
[0029] [029] Examples of inorganic particulate materials include clay, talc, calcite, dolomite, silica, and aluminosilicate, most preferably calcite, dolomite or silica. Examples of oils include mineral oils, vegetable oils, and oils derived from petroleum and waxes. Examples of solvents include alcohols, ethers and acetone.
[0030] [030] Starch can be natural, starch obtained from food grains or it can be a modified starch.
[0031] [031] In particular, the vehicles are preferably water or oil, more preferably, the vehicle being a mixture of water and oil. However, water / solvent mixtures can also be used. In such cases, a suitable solvent is an alcohol. Preferred alcohols are ethanol or isopropyl alcohol. When alcohol is present in the composition, it is preferably present in 2 to 20% by weight of the composition.
[0032] [032] In most applications contemplated as washing / personal care, oral care and cleaning of rigid surface, the antimicrobial composition can be formulated in an aqueous base (where water is the vehicle), for example, products in gel format or purely in oil / solvent. However, more preferably, the shape of the product has an emulsion base (water and oil being the vehicle), for example, liquid soap products, solid, lotion or semi-solid form to wash hands, wash the face, wash the body or applications for shaving or waxing; toothpaste / dentifrices for oral care, applications or products for cleaning a rigid surface in the form of a bar or liquid.
[0033] [033] The preferred vehicle for personal washing, rigid surface cleaning and oral care applications is water. In these applications, the compositions are preferably not anhydrous. SURFACTANT
[0034] [034] The antimicrobial composition preferably comprises 1 to 80% surfactant. In general, surfactants can be chosen from surfactants described in well-known literature such as "Surface Active Agents" Vol. 1, by Schwartz & Perry, Interscience 1949, Vol. 2 by Schwartz, Perry & Berch, Interscience 1958, and / or a current edition of "McCutcheon's Emulsifiers and Detergents" published by Manufacturing Confectioners Company or in "Tenside-Taschenbuch", H. Stache, 2nd edition, Carl Hauser Verlag, 1981. Any type of surfactant, that is, anionic, cationic, ion, zwitterionic (polar ion); zwitterionic (polar ion) or amphoteric can be used.
[0035] [035] A preferred surfactant, particularly, is soap. The soap is a surfactant suitable for personal washing applications of the antimicrobial composition of the invention. The soap is preferably C8-C24 soap, more preferably C10-C20 soap and, even more preferably, C12-C16 soap. The soap may or may not have one or more carbon-carbon double-bonded or triple-bonded. The soap cation can be alkali metal, alkaline earth metal or ammonium.
[0036] [036] Preferably, the soap cation is selected from sodium, potassium or ammonium. Most preferably, the soap cation is sodium or potassium.
[0037] [037] Soap can be obtained through the saponification of a fat and / or fatty acid. The fats or oils commonly used in soap making can be, for example, tallow, tallow stearins, palm oil, palm stearin, soybean oil, fish oil, castor oil, rice bran oil, sunflower oil, coconut oil, babassu oil, palm kernel oil, and others. In the above process, fatty acids are derived from selected oils / fats from coconut, rice bran, peanuts, tallow, palm, palm kernel, cottonseed, soy, castor, etc. Fatty acid soaps can also be prepared synthetically (for example, through the oxidation of petroleum or through the hydrogenation of carbon monoxide through the Fischer-Tropsch process). Resin acids, such as those present in tall oil, can be used. Naphthenic acids are also suitable.
[0038] [038] Tallow fatty acids can be derived from various animal sources and generally comprise about 1 to 8% myristic acid, about 21 to 32% palmitic acid, about 14 to 31% stearic acid, about 0 to 4% palmitoleic acid, about 36 to 50% oleic acid and about 0 to 5% linoleic acid. A typical distribution is about 2.5% myristic acid, about 29% palmitic acid, about 23% stearic acid, about 2% palmitoleic acid, about 41.5% oleic acid, and about 3 % linoleic acid. Other similar mixtures, such as those of palm oil and those derived from tallow from various animals and lard are also included.
[0039] [039] Coconut oil refers to fatty acid mixtures that have a carbon chain length distribution of about 8% C8, about 7% C10, about 48% C12, about 17% C14, about 8% C16, about 2% C18, about 7% oleic acid and about 2% linoleic acid (the first six fatty acids listed are saturated). Other sources, which have similar carbon chain fulfillment distributions, such as palm kernel oil and babassu kernel oil, are included in the term coconut oil.
[0040] [040] A typical fatty acid mixture consisted of 5 to 30% coconut fatty acids and 70 to 95% fatty acids available with hardened rice bran oil. Fatty acids derived from suitable oils / fats such as peanuts, soybeans, tallow, palm, palm kernel, etc. they can also be used in other desired proportions. The most preferred soap is a laurate soap. Soap, when present in solid forms of the present invention, is present in an amount of 30 to 90%, preferably 50 to 85%, more preferably 55 to 75% by weight of the composition. Soap, when present in liquid forms of the present invention, is present in 0.5 to 20%, preferably from 1 to 10% by weight of the composition.
[0041] [041] The antimicrobial composition of the invention is useful in rigid surface cleaning applications. In such applications, the preferred surfactants are non-ionic surfactants, such as C8-C22, preferably, fatty alcohol C8-C16 ethoxylates, which comprise between 1 and 8 ethylene oxide groups when the product is in liquid form. When the product is in solid form for rigid surface cleaning applications, surfactants are preferably selected from primary alkyl sulfate, secondary alkyl sulfonate, alkyl benzene sulfonate, or ethoxylated alkyl sulfonate. The composition can additionally comprise an anionic surfactant such as an alkyl ether sulfate, preferably those having between 1 and 3 ethylene oxide groups, both from natural or synthetic sources and / or sulfonic acid. Sodium luryl ether sulfate is especially preferred. The alkyl polyglycoside may still be present in the composition, preferably those that have a carbon chain length between C6 and C16. Suitable surfactant concentrations in liquid forms of application for cleaning hard surfaces are generally more than 0.5, but less than 10%, preferably 1 to 5% by weight of the composition. In solid compositions, the surfactant is preferably present in 5 to 40%, preferably from 10 to 30% by weight of the composition.
[0042] [042] The antimicrobial composition of the invention is useful in oral care compositions, for example, in a toothpaste / toothpaste or mouthwash. In such applications, the preferred surfactants are of an anionic, non-ionic or amphoteric nature, preferably, anionic or amphoteric. The anionic surfactant is preferably an alkali metal alkyl sulfate, more preferably, a sodium lauryl sulfate (SLS). Mixtures of anionic surfactants can also be used. The amphoteric surfactant is preferably a betaine, more preferably an alkyl starch propyl betaine (where the alkyl group is a C10-C18 straight chain), and most preferably, it is cocoamido proplia betaine (CAPB). Mixtures of amphoteric surfactants can also be used. Adequate concentrations of surfactant in oral care applications, in general, are from about 2% to about 15%, preferably from about 2.2% to about 10%, more preferably, from about 2.5 to about 5% by weight of the total composition.
[0043] [043] Thus, in a highly preferred aspect, antimicrobial compositions include soap, alkyl sulfate or linear alkyl benzene sulfonate such as surfactants.
[0044] [044] The composition of the invention is especially suitable for use in a washing removal process where the contact time of antimicrobial activities with the surface is short, that is, on the order of less than 5 minutes, preferably less than 2 minutes , more preferably, less than a minute and, in many cases, less than 15 seconds.
[0045] [045] A further advantage of the present invention is that it is observed that such surfaces treated with a composition comprising terpineol, thymol, and eugenol, surprisingly, allow the continued protection of the surface against the growth of microbes for a period of time substantial. ADDITIONAL INGREDIENTS
[0046] [046] The composition may further comprise several additional ingredients known to a person skilled in the art. Such additional ingredients include, but are not limited to: perfumes, pigments, preservatives, emollients, sunscreens, emulsifiers, gelling agents, or thickening agents. The composition of the invention may further comprise antimicrobial assets in addition to eugenol, thymol and terpineol. Such antimicrobial activities may be trichloro carbanilide (TCC), triclosan (TCN), a zinc compound, for example, (zinc pyrithione) or benzalkonium chloride (BKC), preferably benzalkonium chloride. Such additional antimicrobial activity can be present in 0.1 to 5% by weight, preferably from 0.5 to 4% by weight of the composition. FORMAT
[0047] [047] The antimicrobial composition can be in the form of a solid, a liquid, a gel, or a paste. Alternatively, the composition can be released onto surfaces in the form of a spray. A person skilled in the art can prepare compositions in various formats by choosing one or more carrier and / or surfactant materials. The antimicrobial compositions of the present invention are useful for cleaning and care, in particular, skin cleaning and skin care. It is contemplated that the antimicrobial composition can be used as a product without rinsing or a product with a wash, preferably a product with a wash. The antimicrobial composition of the present invention can also be used for cleaning and caring for rigid surfaces such as glass, metal, plastic and the like. An especially useful way of releasing the composition of the invention on rigid surfaces is through the sprinkler shape.
[0048] (a) 0,005 a 5% em peso de eugenol; (b) 0,01 a 5% em peso de timol; (c) 0,01 a 5% em peso de terpineol; (d) 10 a 99% em peso de água; e (e) 0,1 a 30% em peso de tensoativo [048] According to one aspect, water is a preferred vehicle. When water is the vehicle, a preferred liquid composition comprises: (a) 0.005 to 5% by weight of eugenol; (b) 0.01 to 5% by weight of thymol; (c) 0.01 to 5% by weight of terpineol; (d) 10 to 99% by weight of water; and (e) 0.1 to 30% by weight of surfactant
[0049] [049] The liquid antimicrobial composition is useful for cleaning the skin, in particular for washing hands or face. Another very useful liquid antimicrobial composition is used to disinfect hard surfaces, fabrics, diapers, skin surfaces that may be cut or scratched on the cheeks and neck after shaving. Such liquid compositions are often called liquid antiseptic compositions, and such compositions are often used after being diluted with water. Suitable composition: the water to dilution ratio is in the range of 1: 2 to 1: 500, more preferably, 1:10 to 1: 400, even more preferably about 1:10 to 1:50. It is particularly preferred that such liquid antiseptic compositions comprise a cationic surfactant. Most preferably the cationic surfactant is benzalkonium chloride. Benzalkonium chloride, when included, is preferably present in 1 to 10%, preferably 1 to 5% by weight of the composition.
[0050] (a) 0,005 a 5% em peso de eugenol; (b) 0,01 a 5% em peso de timol; (c) 0,01 a 1,5% em peso de terpineol; (d) 5 a 30% em peso de água; e (e) 30 a 90% em peso de tensoativo. [050] When water is the vehicle, a preferred solid composition comprises: (a) 0.005 to 5% by weight of eugenol; (b) 0.01 to 5% by weight of thymol; (c) 0.01 to 1.5% by weight of terpineol; (d) 5 to 30% by weight of water; and (e) 30 to 90% by weight of surfactant.
[0051] [051] The solid antimicrobial composition is preferably in the form of a molded solid, more preferably, a bar. The solid antimicrobial composition is particularly useful for cleaning the skin, in particular for washing hands and face. In the solid antimicrobial composition, the surfactant is preferably soap.
[0052] [052] According to another aspect, inorganic particulate material is also a suitable vehicle. When inorganic particulate material is the carrier, the antimicrobial composition is in a solid form. Preferably, the inorganic particulate material is talc. When the inorganic particulate material is talc, the solid antimicrobial composition is particularly useful as a talcum powder for application on the face or body.
[0053] [053] According to an additional aspect, the solvent is a preferred vehicle. Although any solvent can be used, alcohol is a preferred solvent. Short-chain alcohols, in particular ethanol and propanol, are particularly preferred vehicles for an antimicrobial handkerchief or an antimicrobial hand sanitizing composition.
[0054] [054] In accordance with an aspect of the present invention, a method of disinfecting a surface is provided (i) comprising the steps of: (a) 0.005 to 5% by weight of eugenol; (b) 0.01 to 5% by weight of terpineol; (c) 0.01 to 5% by weight of thymol; and (d) a vehicle; on a surface; and (ii) washing the surface with a suitable solvent or cleaning the surface with a suitable tissue.
[0055] [055] The solvent for washing the surface is preferably water, but it could still be a mixture of water and oil. The word “wash” in this document includes the act of wiping the surface with the appropriate handkerchief. In this way, the surface, for example, hand, face, body, oral cavity, or any rigid surface, for example, a utensil, comes into contact with the composition of the invention first. It is then preferably washed with sufficient amounts of water after a predetermined period of time to remove any residue from the visible or sensory composition. Alternatively, an alcohol-based handkerchief or an alcohol-soaked handkerchief can be used to clean the surface so that it is visibly free of the antimicrobial composition. The substrate washing step is preferably carried out for less than 5 minutes, more preferably less than 2 minutes, even more preferably less than one minute and, in many cases, less than 15 seconds after the composition application step. on the substrate.
[0056] [056] The method for disinfecting the surface preferably comprises applying a composition comprising (a) 0.03 to 0.4% by weight of eugenol; (b) 0.03 to 0.6% by weight of thymol; 0.06 to 1.5% by weight of terpineol; and a vehicle on the surface before the washing or cleaning step. The composition useful in the disinfection method preferably comprises 1 to 80% surfactant. The surfactant is preferably anionic. Another aspect is that the surfactant is cationic. The cationic surfactant is preferably benzalkonium chloride. When benzalkonium chloride is present, it is preferably in 0.1 to 5% by weight of the composition.
[0057] [057] According to a preferred aspect, the invention provides non-therapeutic benefits.
[0058] [058] Thus, in accordance with yet another aspect of the invention, the use of a composition comprising 0.005 to 5% by weight of eugenol is provided; 0.01 to 5% by weight of thymol, 0.01 to 5% by weight of terpineol, and a vehicle for a faster reduction in microbial count.
[0059] [059] In accordance with yet another aspect of the invention, the use of a composition comprising 0.005 to 5% by weight of eugenol is provided; 0.01 to 5% by weight of thymol, 0.01 to 5% by weight of terpineol, and a vehicle for improving the hygiene of human body surfaces. Human surfaces include skin, hands and oral cavity.
[0060] [060] The invention thus provides the use of a composition comprising 0.005 to 5% by weight of eugenol, 0.01 to 5% by weight of thymol, 0.01 to 5% by weight of terpineol, and a vehicle to improve hand hygiene.
[0061] [061] The invention further provides the use of a composition comprising 0.005 to 5% by weight of eugenol, 0.01 to 5% by weight of thymol, 0.01 to 5% by weight of terpineol, and a vehicle to improve oral hygiene.
[0062] [062] The invention further provides the use of a composition comprising 0.005 to 5% by weight of eugenol, 0.01 to 5% by weight of thymol, 0.01 to 5% by weight of terpineol, and a vehicle to improve rigid surface hygiene.
[0063] [063] The invention further provides therapeutic benefits.
[0064] [064] Thus, according to yet another aspect of the present invention, a composition is provided which comprises 0.005 to 5% by weight of eugenol, 0.01 to 5% by weight of thymol, 0.01 to 5% by weight terpeneol, and a vehicle for faster reduction in microbial count. EXAMPLES
[0065] [065] The invention will now be demonstrated with examples. The examples are meant to illustrate only and do not limit the scope of the statements in any way. EXAMPLES 1 TO 3: SYNERGIC INTERACTION BETWEEN EUGENOL AND THE COMBINATION OF TIMOL AND TERPINEOL IN THE SUPPLY OF THE EXTERMINATION OF BACTERIA IN SHORT-TIME TABLES (15 SECONDS)
[0066] [066] Compositions comprising active / active are prepared with water as a vehicle as shown in Table 1 below. Terpineol, thymol and eugenol were obtained from Nishant aromas, India.
[0067] [067] About 107 bacterial cells (E.Coli ATCC 10536) were inserted into a test tube and placed in contact with various compositions for a period of 15 seconds. The bacteria were removed after 15 seconds of contact and the presence of viable cells was determined by neutralizing the antimicrobial, serial dilution and leafing on agar plates. The data are presented in Table 1 as a log (E.Coli Viable) which is the log10 of the number of viable E.coli remaining after 15 seconds of contact. Thus, if 104 remains, log (Viable E. Coli) is 4.
[0068] [068] The data in Table 1 is an average result from four experiments.
[0069] [069] The data in Table 1 indicates that there is a synergistic interaction when eugenol is used together with the combination of thymol and terpineol in providing bactericidal extermination in very short time frames. EXAMPLES 4 TO 7: THE BACTERICIDE EFFECTIVENESS OF TIMOL, TERPINEOL AND ITS COMBINATIONS WITH EUGENOL
[0070] [070] Various compositions, as shown in Table 2, were prepared using the same procedure as used for examples 1 to 3 and bactericidal efficacy was assessed using the same procedure as used to evaluate Examples 1 to 3. Information on bactericidal efficacy is shown in Table 2.
[0071] [071] The data in Table 2 read together with the data in Table 1 indicate that each of the three ingredients, thymol, terpineol or eugenol, individually or any of their binary mixtures are unable to provide a bactericidal mixture as good as a ternary mixture. of the three ingredients. In fact, the information indicates synergistic bactericidal efficacy. EXAMPLES 8 TO 10: ANTIMICROBIAL EFFECTIVENESS OF ANOTHER COMPOSITION OF THE INVENTION
[0072] [072] The compositions, as summarized in Table 3, were prepared using a procedure similar to that used in Examples 1 to 3 and bactericidal efficacy was assessed using a procedure similar to that used to evaluate Examples 1 to 3. information on bactericidal efficacy is summarized in Table 3.
[0073] [073] The data in Table 3 indicates that a similar synergy is observed in another set of concentrations (concentrations lower than those used in Table 1) of thymol, terpineol, and eugenol. EXAMPLES 11 TO 13: LIQUID ANTISEPTIC COMPOSITIONS THAT UNDERSTAND BENZALKONIUM CHLORIDE
[0074] [074] Liquid antiseptic compositions as shown in Table 4 were prepared. The various compositions were diluted with water in a composition: water ratio of 1: 400 and then tested for bactericidal efficacy. The procedure used was similar to that used in Examples 1 to 3. The data on bactericidal efficacy are summarized in Table 4.
[0075] [075] The data in Table 4 indicates that such a combination of terpineol, thymol and eugenol interacts synergistically with benzalkonium chloride to provide a major improvement in bactericidal efficacy. EXAMPLES 14 TO 16: COMPOSITION OF BAR SOAP
[0076] [076] Bar soap compositions were prepared by conventional procedure to prepare ground and extruded soap bars. The compositions of the various bars of soap are summarized in Table 5. The solutions of the bars of soap at 8% concentration in water were prepared and used to test the bactericidal efficacy using a procedure similar to that used for Examples 1 to 3, except that 106 of viable bacteria were used. The information is reduced in Table 5.
[0077] [077] The data in Table 5 indicates that the soap with thymol and terpineol provides a 10 times greater bacterial removal compared to a conventional bactericidal soap (which contains CBT, that is, Trichloro carbanilide). Compared to the same, a bar of soap of the present invention, which further comprises eugenol (Example 16) provides 20 times better bactericidal removal. EXAMPLE 17: ORAL CARE COMPOSITION
[0078] [078] Good bactericidal compositions for oral care were prepared as shown in Table 6.

权利要求:
Claims (14)
[0001]
NON-THERAPEUTIC METHOD FOR DISINFECTING A SURFACE, characterized by understanding the steps of: (i) applying a composition that comprises: (a) 0.005 to 5% by weight of eugenol; (b) 0.01 to 5% by weight of terpineol; (c) 0.01 to 5% by weight of thymol; and (d) a vehicle that comprises water; to a surface; and (ii) wash the surface with a suitable solvent or clean the surface with a suitable tissue.
[0002]
METHOD, according to claim 1, characterized in that said steps of washing or cleaning the surface are carried out in less than 5 minutes after the step of applying the composition on the surface.
[0003]
METHOD according to any one of claims 1 to 2, characterized in that said composition comprises: (a) 0.03 to 0.4% by weight of eugenol; (b) 0.03 to 0.6% by weight of thymol; (c) 0.06 to 1.5% by weight of terpineol; and (d) a vehicle that comprises water.
[0004]
METHOD according to any one of claims 1 to 3, characterized in that it comprises 1 to 80% surfactant.
[0005]
METHOD, according to claim 4, characterized in that said surfactant is anionic.
[0006]
METHOD according to any one of claims 1 to 5, characterized in that said composition comprises benzalkonium chloride.
[0007]
ANTIMICROBIAL COMPOSITION, characterized by comprising: (a) 0.005 to 5% by weight of eugenol; (b) 0.01 to 5% by weight of terpineol; (c) 0.01 to 5% by weight of thymol; (d) 1 to 80% by weight of a surfactant; and (e) a vehicle that comprises water.
[0008]
LIQUID ANTIMICROBIAL COMPOSITION, as defined in claim 7, characterized by comprising: (a) 0.005 to 5% by weight of eugenol; (b) 0.01 to 5% by weight of thymol; (c) 0.01 to 5% by weight of terpineol; (d) 10 to 99% by weight of water; and (e) 1 to 30% by weight of surfactant.
[0009]
COMPOSITION, according to claim 8, characterized in that said surfactant is a cationic surfactant.
[0010]
SOLID ANTIMICROBIAL COMPOSITION, as defined in claim 7, characterized by comprising: (a) 0.005 to 5% by weight of eugenol; (b) 0.01 to 5% by weight of thymol; (c) 0.01 to 5% by weight of terpineol; (d) 5 to 30% by weight of water; and (e) 30 to 80% by weight of surfactant.
[0011]
COMPOSITION, according to claim 10, characterized in that said surfactant is a soap.
[0012]
NON-THERAPEUTIC USE OF A COMPOSITION, characterized by comprising 0.005 to 5% by weight of eugenol, 0.01 to 5% by weight of thymol, 0.01 to 5% by weight of terpineol, and a vehicle comprising water to improve the hand hygiene by reducing microbial count.
[0013]
NON-THERAPEUTIC USE OF A COMPOSITION, characterized by comprising 0.005 to 5% by weight of eugenol, 0.01 to 5% by weight of thymol, 0.01 to 5% by weight of terpineol, and a vehicle comprising water to improve the oral hygiene by reducing microbial count.
[0014]
USE OF A COMPOSITION, characterized by comprising 0.005 to 5% by weight of eugenol, 0.01 to 5% by weight of thymol, 0.01 to 5% by weight of terpineol, and a vehicle comprising water to improve hygiene of rigid surface by reducing microbial count.

类似技术:

公开号 | 公开日 | 专利标题

BR112012006614B1|2021-02-17|non-therapeutic method to disinfect a surface, antimicrobial compositions, non-therapeutic uses of a composition and use of a composition

JP5592891B2|2014-09-17|Antimicrobial composition

EP2787956B1|2016-02-03|An anti bacterial composition

JP6130854B2|2017-05-17|Antibacterial composition

JP2015500819A|2015-01-08|Antibacterial composition

JP2015500817A|2015-01-08|Antibacterial composition

JP2015505835A|2015-02-26|Antibacterial composition

BR112015004813B1|2021-02-02|soap composition, method of disinfecting a surface and uses of a composition

JP2015500818A|2015-01-08|How to disinfect the surface

BR112014013033B1|2019-12-03|microbicidal composition, non-therapeutic method for providing a microbicidal effect to the skin and non-therapeutic use of a composition

WO2013034416A1|2013-03-14|Antimicrobial method and composition

WO2013034581A1|2013-03-14|Antimicrobial composition comprising thymol and a terpinyl derivative

JP2017171676A|2017-09-28|Antimicrobial compositions

JP2017164524A|2017-09-21|Antimicrobial method and antimicrobial composition

EP2759199A1|2014-07-30|A method of providing antimicrobial action and a synergistic antimicrobial composition thereof

同族专利:

公开号 | 公开日

CL2012000716A1|2013-01-25|

MY155945A|2015-12-31|

JP2013505907A|2013-02-21|

CA2801143C|2017-09-26|

AU2010297406B2|2013-10-17|

AR078310A1|2011-10-26|

US9132103B2|2015-09-15|

PL2480090T3|2014-04-30|

ES2437919T3|2014-01-15|

CN102510723B|2016-08-10|

EP2480090A1|2012-08-01|

EP2480090B1|2013-11-06|

CA2801143A1|2011-03-31|

WO2011036048A1|2011-03-31|

US20120276022A1|2012-11-01|

CN102510723A|2012-06-20|

AU2010297406A1|2012-04-05|

EA019746B1|2014-05-30|

ZA201201831B|2013-05-29|

EA201200531A1|2012-09-28|

MX2012003563A|2012-04-30|

JP5844260B2|2016-01-13|

BR112012006614A2|2020-08-11|

引用文献:

公开号 | 申请日 | 公开日 | 申请人 | 专利标题

US658596A|1900-05-23|1900-09-25|William Edmund Simpson|Lubricator.|

FR718325A|1931-06-06|1932-01-23|Naamlooze Vennootschap Vereeni|Process for perfuming toilet soaps|

US2196763A|1938-01-21|1940-04-09|Eastman Kodak Co|Liquid antiseptic soap|

GB508407A|1938-03-08|1939-06-30|Thomas Lewis Shepherd|A new and improved disinfectant insecticidal, fungicidal, vermin destroying and therapeutic substance and method of making the same|

FR861920A|1938-11-09|1941-02-21|Ste Ind Chim Bale|Cellulose compounds containing sulfur and nitrogen|

US2359241A|1942-07-31|1944-09-26|Dow Chemical Co|Liquid germicidal compositions|

FR1356209A|1959-09-24|1964-03-27|Process for obtaining a dental product and product thus obtained|

US3256310A|1962-11-08|1966-06-14|Fmc Corp|Spirocyclic borate esters|

FR157M|1966-02-08|Lepetit Spa|Steroid compounds.|

US3787566A|1969-07-29|1974-01-22|Holliston Labor Inc|Disinfecting aerosol compositions|

GB1365062A|1970-07-01|1974-08-29|Bush Boake Allen Ltd|Compounded perfumery compositions containing organic titanates or zirconates|

FR2165741B1|1971-12-28|1975-03-14|Fr|

GB1420946A|1972-10-13|1976-01-14|Beecham Group Ltd|Anti-bacterial compositions|

US4267168A|1977-03-11|1981-05-12|Aquatain Partnership|Method of reducing bacteria on human tissue using liquid biocidal compositions comprising a mixture of silver ions and sodium pectate|

DE2445676C2|1974-09-25|1985-09-19|Galenika Dr. Hetterich GmbH, 8510 Fürth|toothpaste|

DE3117792C2|1981-05-06|1990-08-23|Schülke & Mayr GmbH, 2000 Norderstedt|The use of an aqueous solution of alcohols, phenols and surfactants as a virucidal agent|

JPH0345044B2|1982-04-30|1991-07-09|Kowa Co|

GB8314710D0|1983-05-27|1983-07-06|Optikon Ltd|Cleaning compositions|

JPH0311013B2|1983-07-19|1991-02-15|Sanyo Electric Co|

US4548809A|1984-03-27|1985-10-22|Fung Paul S T|Method for manufacturing a stomatic gargle|

US4966754A|1988-08-08|1990-10-30|Aveda Corporation|Preservation of cosmetic compositions|

US5013486A|1989-04-28|1991-05-07|Colgate-Palmolive Company|Detergent bar with improved stain removing and antibacterial properties|

US5073366A|1989-05-30|1991-12-17|Fred Beck|Analgesic composition useful in providing a temporary relief from symptoms of arthritis|

SU1644963A1|1989-08-22|1991-04-30|Ленинградский Государственный Институт Усовершенствования Врачей Им.С.М.Кирова|Tooth paste|

JPH0327533B2|1989-10-17|1991-04-16|Kowa Co|

DE59010243D1|1989-12-19|1996-05-02|Hoffmann La Roche|Halophenyl substituted dioxanes|

US4992259A|1990-01-03|1991-02-12|Johnson & Johnson Consumer Products, Inc.|Stable oral composition of zinc|

AU1890292A|1991-04-19|1992-11-17|Procter & Gamble Company, The|Antimicrobial oral compositions|

FR2697133B1|1992-10-28|1995-01-13|Transbiotech|Biocidal and / or biostatic composition and its applications.|

US5474761A|1993-04-08|1995-12-12|The Procter & Gamble Company|Oral compositions for treating plaque and gingivitis|

DE69422081T2|1993-04-19|2000-07-20|Reckitt & Colman Inc|General purpose detergent composition|

US5472684A|1993-06-02|1995-12-05|Colgate Palmolive Company|Oral compositions for plaque and gingivitis|

US5283056A|1993-07-01|1994-02-01|International Flavors & Fragrances Inc.|Transparent oil-in-water microemulsion flavor or fragrance concentrate, process for preparing same, mouthwash or perfume composition containing said transparent microemulsion concentrate, and process for preparing same|

DE69428847T2|1993-08-19|2002-04-11|Kao Corp|Germicidal and disinfectant detergent and cleaning agent composition|

US5585343A|1993-11-02|1996-12-17|Givaudan-Roure Corporation|Low VOC perfume formulations|

US6576247B1|1994-11-10|2003-06-10|Kanebo Ltd. And T. Hasegawa Co. Ltd.|Sustained-release aromatic and method of detecting micro-organism by using the same|

US6277805B1|1993-11-22|2001-08-21|The Procter & Gamble Co.|Alkaline liquid hard-surface cleaning composition containing a quaternary ammonium disinfectant and selected dicarboxylate sequestrants|

ES2074030B1|1994-01-31|1996-02-01|S A L V A T Lab Sa|CARRIER, SELF-HEATING AND APPLICABLE COMPOSITIONS IN THERAPEUTICS BY VIA TOPICA.|

CA2143037C|1994-05-02|2002-04-30|Atma Chaudhari|Alcohol free mouthwash|

JP3081766B2|1994-05-06|2000-08-28|東興薬品工業株式会社|Keratin storage type antifungal external composition|

FR2725621B1|1994-10-13|1997-02-21|

FR2727289B1|1994-11-30|1999-03-05|Derives Resiniques Terpenique|DISINFECTANT COMPOSITION COMPRISING AT LEAST ONE TERPENIC ALCOHOL AND AT LEAST ONE BACTERICIDIC ACID SURFACTANT, AND USE OF SUCH SURFACTANTS|

US5474712A|1995-01-10|1995-12-12|Citra Science, Ltd.|Livestock conditioning shampoo|

DE19509079A1|1995-03-15|1996-09-19|Beiersdorf Ag|Cosmetic or dermatological microemulsions|

GB2304111A|1995-08-04|1997-03-12|Reckitt & Colman Inc|Pine oil cleaning composition|

US5942478A|1995-09-19|1999-08-24|Lopes; John A.|Microbicidal and sanitizing soap compositions|

SI0854702T1|1995-10-11|2005-06-30|Warner-Lambert Company Llc|Antimicrobial compositions containing a c 3-c 6 alcohol|

WO1997015277A1|1995-10-23|1997-05-01|Warner-Lambert Company|Enhanced stannous oral composition|

GB2307915B|1995-11-14|1997-11-05|Reckitt & Colman Inc|Improved compositions containing organic compounds|

US6048368A|1995-11-27|2000-04-11|The Proctor & Gamble Company|Cleaning method for textile fabrics|

US6248705B1|1996-01-12|2001-06-19|The Procter & Gamble Company|Stable perfumed bleaching compositions|

WO1997025106A1|1996-01-12|1997-07-17|The Procter & Gamble Company|Disinfecting compositions and processes for disinfecting surfaces|

AU715429B2|1996-02-23|2000-02-03|Procter & Gamble Company, The|Disinfecting compositions|

EP0791362A3|1996-02-23|1998-03-04|The Procter & Gamble Company|Disinfecting compositions and processes for disinfecting surfaces|

HU9901063A3|1996-02-23|2000-09-28|Procter & Gamble|Disinfecting compositions and processes for disinfecting surfaces|

GB9613967D0|1996-07-03|1996-09-04|Unilever Plc|Improvements relating to antimicrobial cleaning compositions|

BR9603085A|1996-07-12|1998-05-05|Cosmeticos Natural Ind Com|Liquid antiseptic soap for skin care|

CZ13599A3|1996-07-16|1999-05-12|The Procter & Gamble Company|Use of combination of surface-active agents, chelate forming agents and essential oils for effective disinfection|

US6147047A|1996-08-09|2000-11-14|The Clorox Company|Microemulsion dilutable cleaner|

FR2752730A1|1996-08-30|1998-03-06|Argelas Daniel|Aqueous washing agent for hair and scalp containing no surface active detergents or foaming agents|

AU4428397A|1996-09-20|1998-04-14|Warner-Lambert Company|Oral compositions containing a zinc compound|

GB9623377D0|1996-11-09|1997-01-08|Reckitt & Colmann Prod Ltd|Organic compositions|

US6114298A|1996-11-13|2000-09-05|The Procter & Gamble Company|Hard surface cleaning and disinfecting compositions comprising essential oils|

GB2320030A|1996-12-06|1998-06-10|Reckitt & Colman Inc|Disinfecting and cleaning compositions|

GB2320927B|1997-01-06|2001-04-18|Reckitt & Colman Inc|Germicidal hard surface cleaner|

CH692411A5|1997-01-20|2002-06-14|Orphea Sa|Well tolerated aqueous insect repellent gel for skin protection, containing carbomer, polyoxyethylene hydrogenated castor oil, denatured ethanol and citronella and geranium essential oils|

GB2322552B|1997-03-01|2001-05-16|Reckitt & Colman Inc|Liquid disinfectant concentrate|

US6224899B1|1997-03-18|2001-05-01|Kobayashi Pharmaceutical Co., Ltd.|Adhesive cooling composition and process for its preparation|

US5945088A|1997-03-31|1999-08-31|Pfizer Inc|Taste masking of phenolics using citrus flavors|

WO1998044959A1|1997-04-04|1998-10-15|Ricom Corporation|Deodorant|

US5939050A|1997-04-04|1999-08-17|Optiva Corp.|Antimicrobial compositions|

KR20010013210A|1997-05-30|2001-02-26|데이비드 엠 모이어|Disinfecting compositions and processes for disinfecting surfaces|

US6190674B1|1997-06-04|2001-02-20|Procter & Gamble Company|Liquid antimicrobial cleansing compositions|

AU7704698A|1997-06-04|1998-12-21|Procter & Gamble Company, The|Liquid antimicrobial cleansing compositions which provide residual benefit versus gram negative bacteria|

WO1998055093A1|1997-06-04|1998-12-10|The Procter & Gamble Company|Mild, rinse-off antimicrobial liquid cleansing compositions|

EP0984769A1|1997-06-04|2000-03-15|The Procter & Gamble Company|Mild, antimicrobial wipes|

US6210695B1|1997-06-04|2001-04-03|The Procter & Gamble Company|Leave-on antimicrobial compositions|

AU7803598A|1997-06-04|1998-12-21|Procter & Gamble Company, The|Mild, rinse-off antimicrobial liquid cleansing compositions|

US6455086B1|1998-06-26|2002-09-24|The Procter & Gamble Company|Microorganism reduction methods and compositions for food cleaning|

EP0916718A1|1997-10-14|1999-05-19|The Procter & Gamble Company|Cleaning and disinfecting compositions|

US6261540B1|1997-10-22|2001-07-17|Warner-Lambert Company|Cyclodextrins and hydrogen peroxide in dental products|

EP0916720A1|1997-11-17|1999-05-19|The Procter & Gamble Company|Anti-bacterial liquid dishwashing detergent compositions|

US5968986A|1997-12-18|1999-10-19|Woodward Laboratories, Inc.|Antimicrobial nail coating composition|

US5965518A|1998-02-23|1999-10-12|Nakatsu; Tetsuo|Fragrance compositions having antimicrobial activity|

EP0948892A1|1998-04-08|1999-10-13|The Procter & Gamble Company|Disinfecting compositions and processes for disinfecting surfaces|

US6177388B1|1998-04-14|2001-01-23|Reckitt Benckiser Inc.|Botanical oils a blooming agents in hard surface cleaning compositions|

SE9801742L|1998-05-18|1999-11-19|Akzo Nobel Nv|Use of natural substances containing thymol in the preparation of animal feed|

EP0966883A1|1998-06-26|1999-12-29|The Procter & Gamble Company|The use of an anti-microbial compound for disinfection|

AU3765999A|1998-06-29|2000-01-17|Warner-Lambert Company|Improved oral compositions for control and prevention of tartar, oral malodor, plaque and gingivitis|

JP2000026260A|1998-07-13|2000-01-25|Earth Chem Corp Ltd|Oral composition|

JP4814409B2|1998-07-22|2011-11-16|昭神谷|Shampoo composition|

JP2000063262A|1998-08-19|2000-02-29|Osaka Yakuhin Kenkyusho:Kk|Antimicrobial cosmetic composition|

GB2341092B|1998-09-07|2000-12-06|Macgregor Keith Martin|Composition for the removal of biological and organic substances|

DE19841795A1|1998-09-12|2000-03-16|Beiersdorf Ag|Synergistic, selective antimicrobial preparation containing antiadhesive agent, e.g. sterol, and antimicrobial agent, useful e.g. in treating acne or seborrheic dermatitis or as deodorant|

DE19954040A1|1998-10-30|2000-05-04|Gerhard Bundschuh|Use of phenol derivatives, e.g. thymol, as prostaglandin antagonists and antiproliferative agents for treating tumors|

US6656456B2|1998-11-23|2003-12-02|The Procter & Gamble Company|Skin deodorizing compositions|

KR20010080692A|1998-12-07|2001-08-22|스티븐 엠. 베셋트|Cancer Treatment Composition and Method Using Natural Plant Essential Oils|

JP2988928B1|1998-12-18|1999-12-13|三井物産株式会社|Mouth spray composition|

JP3701498B2|1999-01-26|2005-09-28|花王株式会社|Deodorant cleaning agent|

US6183766B1|1999-02-12|2001-02-06|The Procter & Gamble Company|Skin sanitizing compositions|

AU3717100A|1999-03-05|2000-09-21|Ecosmart Technologies, Inc.|Herbicidal compositions containing plant essential oils and mixtures or blends thereof|

US6488943B1|1999-04-13|2002-12-03|The Procter & Gamble Company|Antimicrobial wipes which provide improved immediate germ reduction|

DE19918188A1|1999-04-22|2000-10-26|Cognis Deutschland Gmbh|Cleaning agent, especially for cleaning toilet bowls, is typically in form of high foaming viscous gel and includes ethoxylated fatty amine as a thickener|

US6841577B2|1999-04-29|2005-01-11|Ecosmart Technologies, Inc.|Pesticidal activity of plant essential oils and their constituents|

DE60040464D1|1999-05-26|2008-11-20|Rhodia|BLOCK POLYMERS, COMPOSITIONS AND METHOD FOR USE IN FOAM, DETERGENT, SHOWER CLEANER AND COAGULATING AGENT|

US6861402B1|1999-06-01|2005-03-01|The Procter & Gamble Company|Pro-fragrances|

JP2000344641A|1999-06-02|2000-12-12|Lion Corp|Composition for oral cavity|

US20040067203A1|1999-06-23|2004-04-08|Rita Parikh|Multi-benefit oral hygiene product|

WO2001018201A1|1999-09-09|2001-03-15|Ecosmart Technologies, Inc.|Pesticidal activity of plant essential oils and their constituents|

JP3371098B2|1999-11-04|2003-01-27|花王株式会社|Detergent composition|

AU753853B2|1999-12-14|2002-10-31|Teikoku Seiyaku Co., Ltd|Drugs for relieving hemicrania|

US6436885B2|2000-01-20|2002-08-20|The Procter & Gamble Company|Antimicrobial cleansing compositions containing 2-pyrrolidone-5-carboxylic acid|

EP1121926A1|2000-02-07|2001-08-08|Laboratoires Serobiologiques|Cosmetic preparations containing Waltheria indica extracts|

DE10007322A1|2000-02-17|2001-08-23|Cognis Deutschland Gmbh|Pearlescent agents|

FR2805464B1|2000-02-25|2003-02-14|Serobiologiques Lab Sa|COSMETIC PREPARATIONS CONTAINING EXTRACTS FROM THE PLANT MOURERA FLUVIAUS|

AT313375T|2000-03-04|2006-01-15|Cognis Ip Man Gmbh|MICRO CAPSULES|

EP1301079A2|2000-03-17|2003-04-16|Codena, Inc.|Plant acaricidal compositions and methods|

US20030091657A1|2000-03-17|2003-05-15|Helene Chiasson|Plant acaricidal compositions and method using same|

US6753305B2|2000-04-14|2004-06-22|The Procter & Gamble Company|Process for disinfecting a hard-surface with a composition comprising cinnamon oil and/or an active thereof|

EP1146111A1|2000-04-14|2001-10-17|The Procter & Gamble Company|Process of disinfecting a hard-surface with a composition comprising cinnamon oil and/or an active thereof|

EP1149578A1|2000-04-28|2001-10-31|Laboratoires Serobiologiques|Cosmetic or pharmaceutical compositions containing an Argania Spinosa extract|

EP1166765A3|2000-06-20|2002-05-02|Laboratoires Serobiologiques|Process for protecting human skin|

US8283135B2|2000-06-30|2012-10-09|The Procter & Gamble Company|Oral care compositions containing combinations of anti-bacterial and host-response modulating agents|

EP1343468A1|2000-07-07|2003-09-17|Cognis France S.A.|Method for protecting the skin from aging|

ES2247997T3|2000-09-01|2006-03-16|Cognis Ip Management Gmbh|COSMETIC PREPARATION IN THE FORM OF A BAR.|

KR100356983B1|2000-10-16|2002-10-18|윤경주|Mild composition of cleaning material for clothing|

KR20020032949A|2000-10-28|2002-05-04|손 경 식|Compositions of anti-bacterial gel and methods for preparation thereof|

DE10059239A1|2000-11-29|2002-06-06|Cognis Deutschland Gmbh|Cosmetic and / or pharmaceutical emulsions|

EP1213024A1|2000-12-06|2002-06-12|Laboratoires Serobiologiques|Cosmetic and/or dermopharmaceutical composition containing native proteins of Argania spinosa|

EP1213025A1|2000-12-06|2002-06-12|Laboratoires Serobiologiques|Cosmetic and/or dermopharmaceutical composition containing extracts obtained from the leaves of Argania spinosa|

US6610277B2|2000-12-27|2003-08-26|Arthur Zuckerman|Appetite suppressant toothpaste|

US6531115B1|2001-01-03|2003-03-11|Council Of Scientific & Industrial Research|Analgesic and refreshing herbal composition and a process for preparing the same|

FR2819414A1|2001-01-15|2002-07-19|Cognis France Sa|COSMETIC AND / OR PHARMACEUTICAL PREPARATIONS COMPRISING EXTRACTS FROM PLANTS RESOURCING|

GB0104074D0|2001-02-19|2001-04-04|Novartis Ag|New composition|

DE10118268A1|2001-04-12|2002-10-17|Cognis Deutschland Gmbh|Production of polyetherurethane thickeners useful in cosmetic compositions, involves reacting an ethoxylated fatty alcohol with a diisocyanate|

DE10118269A1|2001-04-12|2002-10-17|Cognis Deutschland Gmbh|Production of polyetherurethane thickeners, useful in cosmetic compositions for, e.g. skin or hair, comprises reacting an ethoxylated fatty alcohol with an aliphatic di- or triisocyanate|

JP4342761B2|2001-04-17|2009-10-14|花王株式会社|Disinfectant composition|

EP1256335A1|2001-05-10|2002-11-13|Cognis France S.A.|Use of procyanidine oligomers|

EP1260212A1|2001-05-21|2002-11-27|Cognis France S.A.|Cosmetic composition|

SK14762003A3|2001-05-31|2004-08-03|Pharmacia Corporation|Skin-permeable composition comprising a selective cyclooxygenase- 2 inhibitor a monohydric alcohol|

EP1262167A1|2001-06-01|2002-12-04|Cognis France S.A.|Cosmetic preparations containing an extract from germinating plants|

FR2826017B1|2001-06-15|2004-06-11|Cognis France Sa|SURFACTANT MIXTURES|

JP2003020495A|2001-07-10|2003-01-24|Cognis Japan Ltd|Oil and fat composition|

US6380152B1|2001-07-12|2002-04-30|Colgate-Palmolive Co.|Antibacterial cleaning wipe comprising triclosan|

CZ297934B6|2001-07-23|2007-05-02|Unilever N. V.|Transparent soap bar|

EP1281392A1|2001-08-02|2003-02-05|Cognis France S.A.|Cosmetic or/and pharmaceutical compositions containing plant extracts|

US7030092B1|2001-08-24|2006-04-18|Small Giant L.L.C.|Ultra-high fiber supplement and method of reducing weight cardiovascular risks and ingested toxins.|

US6902726B1|2001-08-29|2005-06-07|The United States Of America As Represented By The Secretary Of Agriculture|Reduction of odor gases from waste using plant-derived oils|

DE10144264A1|2001-09-08|2003-03-27|Cognis Deutschland Gmbh|Aqueous detergent formulation, useful in cosmetics, e.g. shampoo, hair lotion, foam bath or shower formulation, contains N-acylamino-acid and/or salt and polyol and/or polyol fatty acid ester|

JP2003113013A|2001-09-28|2003-04-18|Lion Corp|Vegetable antimicrobial preservative|

US6846846B2|2001-10-23|2005-01-25|The Trustees Of Columbia University In The City Of New York|Gentle-acting skin disinfectants|

US20060039956A1|2001-10-26|2006-02-23|Hermann Hensen|Impregnating solution for cosmetic cloths|

US6884763B2|2001-10-30|2005-04-26|Permatex, Inc.|Waterless hand cleaner containing plant derived natural essential oil|

DE10160682A1|2001-12-11|2003-06-18|Cognis Deutschland Gmbh|Cosmetic and/or pharmaceutical preparations, e.g. for skin or body care, comprise 2-methyl-1,3-propanediol diesters as emollients, having both lipophilic and hydrophilic properties|

DE10160681A1|2001-12-11|2003-06-18|Cognis Deutschland Gmbh|Cosmetic and/or pharmaceutical preparations, useful e.g. for skin or body care, comprise new or known 2-methyl-1,3-propanediol monoesters as emollients, having both lipophilic and hydrophilic properties|

DE10162026A1|2001-12-18|2003-07-03|Cognis Deutschland Gmbh|Highly concentrated flowable pearlescent concentrates|

DE10162024A1|2001-12-18|2003-07-03|Cognis Deutschland Gmbh|Highly concentrated flowable pearlescent concentrates|

GB2383334A|2001-12-20|2003-06-25|Reckitt Benckiser Inc|Powder detergent compositions|

FR2834718B1|2002-01-15|2004-12-24|Cognis France Sa|COSMETIC AND / OR PHARMACEUTICAL ACTIVE SUBSTANCES|

WO2003070286A1|2002-02-19|2003-08-28|Eden Research Plc|Improvement of indoor air quality and antiseptic composition for use therein|

DE10212528A1|2002-03-21|2003-10-02|Cognis Deutschland Gmbh|Oil phases for cosmetic products|

GB0209198D0|2002-04-23|2002-06-05|Reckitt Benckiser Inc|Improvements in or relating to organic compositions|

US20050169889A1|2002-04-26|2005-08-04|Wellstat Biologics Corporation|Immunogenic agent therapy using plasmapheresis or exchange transfusion|

FR2839516B1|2002-05-13|2006-08-04|Pierre Bruno Grascha|WORKSHOP DETERGENT FORMULATION|

DE10232774B4|2002-07-18|2004-07-15|Cognis Deutschland Gmbh & Co. Kg|Cosmetic preparations with antibacterial properties|

JP4112310B2|2002-08-14|2008-07-02|花王株式会社|Liquid detergent composition|

GB2392166A|2002-08-22|2004-02-25|Reckitt Benckiser Inc|Composition separable into two phases|

US6645472B1|2002-09-13|2003-11-11|Michael R. Anderson|Oral hygiene powder composition and method|

AU2003272892A1|2002-09-26|2004-04-19|Mandom Corporation|Antiseptic bactericides and cosmetics, drugs and foods containing the antiseptic bactericides|

JP3635578B2|2002-09-26|2005-04-06|株式会社マンダム|Antiseptic disinfectant and cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant|

JP2004123674A|2002-10-07|2004-04-22|Noevir Co Ltd|Skin care preparation for external use|

GB2393967A|2002-10-11|2004-04-14|Reckitt Benckiser|Surface treatment composition|

GB2393911A|2002-10-12|2004-04-14|Reckitt Benckiser Inc|Antimicrobial hard surface cleaner|

JP3947149B2|2002-10-28|2007-07-18|高砂香料工業株式会社|Deodorant composition|

EP1562543A1|2002-11-21|2005-08-17|J.P.M.E.D. Ltd.|Compositions for treating infected skin and mucous membrane comprising an anti-microbial agent and an essential oil|

JP2004203839A|2002-12-26|2004-07-22|Takasago Internatl Corp|Perfume composition to suppress iron rust smell|

EP1440683A1|2003-01-23|2004-07-28|Cognis France S.A.|Use of oligoglucosamines in cosmetic or dermatologic compositions|

RU2228168C1|2003-02-05|2004-05-10|Дулькис Мария Дмитриевна|Agent for treatment of parodontium inflammatory diseases|

GB0303678D0|2003-02-18|2003-03-19|Quest Int|Improvements in or relating to flavour compositions|

US20040209795A1|2003-04-21|2004-10-21|Vlad Florin Joseph|VOC-free microemulsions|

DE10319400A1|2003-04-30|2004-11-18|Cognis Deutschland Gmbh & Co. Kg|Use of hydroxy carboxylic acid esters|

FR2854799A1|2003-05-16|2004-11-19|Cognis France Sa|Cosmetic and/or dermatological preparations, useful for treating the skin, scalp or hair, e.g. for combating skin aging and inflammation, containing extracts of seeds of Adenanthera genus plants|

JP2005015368A|2003-06-25|2005-01-20|Saga Seiyaku Kk|Method for stabilizing pranoprofen-containing aqueous liquid preparation|

AU2004258899B2|2003-07-17|2009-09-03|The Trustees Of Columbia University In The City Of New York|Antimicrobial compositons containing synergistic combinations of quaternary ammonium compounds and essential oils and/or constituents thereof|

US6875453B2|2003-07-18|2005-04-05|Manuel Viamonte, Jr.|Non-toxic disinfectant containing a isopropyl alcohol and sesame oil composition with lemon oil and menthol|

US8486374B2|2003-08-04|2013-07-16|Foamix Ltd.|Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses|

JP2005065750A|2003-08-27|2005-03-17|Takasago Internatl Corp|Product containing deodorant|

US7713440B2|2003-10-08|2010-05-11|Lyotropic Therapeutics, Inc.|Stabilized uncoated particles of reversed liquid crystalline phase materials|

US20090165228A1|2004-01-16|2009-07-02|Andrew Kilkenny|Cleaning Composition for Disposable Cleaning Head|

US8067044B2|2004-02-13|2011-11-29|Cognis France S.A.S.|Cosmetic compositions containing an extract of leaves of the Castanea sativa plant and cosmetic treatments|

US7858570B2|2004-02-24|2010-12-28|Hare William D|Compositions and methods for removing urushiol and treating the resulting skin condition|

JP2005239965A|2004-02-27|2005-09-08|Seiko Epson Corp|Aqueous ink composition|

CN1669576A|2004-03-17|2005-09-21|东莞市朗晨生物技术有限公司|Anticarious spray agent and producing process thereof|

RU2263115C1|2004-03-19|2005-10-27|Московский государственный текстильный университет им. А.Н. Косыгина|Modifying agents of textile materials - polyethoxysiloxanes comprising pharmacophore organooxysilyl ligands and method for their preparing|

JP2005298357A|2004-04-07|2005-10-27|Lion Corp|Composition for oral cavity|

JP2007537203A|2004-05-12|2007-12-20|チバ　スペシャルティ　ケミカルズ　ホールディング　インコーポレーテッド|Antibacterial silicon oxide flakes|

EP1607098A1|2004-05-28|2005-12-21|Cognis France, S.A.S.|Cosmetic use of an active ingredient that increases Gadd45 gene expression|

EP1604643A1|2004-06-03|2005-12-14|Cognis France, S.A.S.|Cosmetic use of derivatives of 3-Phenylpropionic acid|

EP1773130A4|2004-06-29|2008-09-03|Univ Victoria|Antimicrobial packaging material|

RU2277923C2|2004-07-08|2006-06-20|Общество с ограниченной ответственностью "Медицинское научно-производственное объединение "Биокон"|Composition for preventing conditions associated with circulation troubles in legs|

ES2427170T3|2004-07-27|2013-10-29|Genprofiler S.R.L.|Mixture of polyphenols for the prevention of the appearance of prostate cancer in a person diagnosed with a high degree of intraepithelial prostate neoplasia |

WO2006012715A1|2004-08-03|2006-02-09|Charilaos Andreopoulos|Composition for treating foot odour and manufacturing process thereof|

DE102004038285A1|2004-08-05|2006-04-27|Beiersdorf Ag|Use of ethereal oils containing a polymer matrix for the production of drug delivery systems for the transdermal and/or by inhalation application of ethereal oils in aroma therapy|

US20060045914A1|2004-08-26|2006-03-02|Isp Investments Inc.|Matrix composition for stable microemulsions|

WO2006034463A2|2004-09-23|2006-03-30|Herbalife International, Inc.|Herbal supplement to support weight loss|

US20070218016A1|2004-09-24|2007-09-20|Symrise Gmbh & Co. Kg|Use of Aroma Substance Mixtures as Agents Against Bad Breath|

JP2006095182A|2004-09-30|2006-04-13|Green:Kk|Cleaning agent extracted from natural product|

WO2006042661A2|2004-10-18|2006-04-27|Cognis France S.A.S|Oligopeptides and their use in cosmetics|

GB0425305D0|2004-11-17|2004-12-15|Givaudan Sa|Bactericidal formulations|

EP1672054A1|2004-11-24|2006-06-21|KAO CHEMICALS GmbH|Carboxymethylated glyceride derivatives as foam-enhancing agents for surfactants|

EP1661976A1|2004-11-24|2006-05-31|KAO CHEMICALS GmbH|Ethercarboxylates and glycerine derivatives as foam-enhancing agent for surfactants|

US20060128585A1|2004-12-15|2006-06-15|Martha Adair|Antimicrobial composition for cleaning substrate|

US8597617B2|2004-12-21|2013-12-03|Colgate-Palmolive Company|Coated natural calcium carbonate oral care toothpowder composition|

US8895084B2|2004-12-23|2014-11-25|Colgate-Palmolive Company|Oral care composition containing extract of unoxidized Camellia|

IL167500A|2005-03-17|2010-12-30|Avner Talmon|Soaps from residues from the processing of plant materials and method of producing the same|

US7943183B2|2005-03-18|2011-05-17|Gardiner Paul T|Compositions and methods for increasing metabolism, thermogenesis and/or muscular definition|

JP2008534675A|2005-04-09|2008-08-28|パイオンテックカンパニーリミテッド|Antibacterial composition containing natural extract, nanosilver, and natural essential oil|

WO2006120495A1|2005-05-13|2006-11-16|Advanced Scientific Developements|Pharmaceutical composition comprising an antiviral agent, an antitumour agent or an antiparasitic agent and an active substance selected from carveol, thymol, eugenol, borneol and carvacrol|

WO2006120494A1|2005-05-13|2006-11-16|Advanced Scientific Developements|Pharmaceutical combination comprising an antibacterial agent and an active substance selected from carveol, thymol, eugenol, borneol and carvacrol|

WO2006120496A1|2005-05-13|2006-11-16|Advanced Scientific Developements|Pharmaceutical combination comprising an antifungal agent and an active substance selected from carveol, eugenol, thymol, borneol and carvacrol|

FR2886516B1|2005-06-02|2007-10-05|Xeda Internat Sa|PROCESS FOR THE ANTI -MINMINATION AND / OR BIOCIDAL TREATMENT OF BULBS OR TUBERS USING CIPC AND TERPENE OR TERPENIC OIL|

ES2462925T3|2006-06-14|2014-05-26|Symrise Ag|Compounds with antimicrobial effect for the treatment of oral fetidity|

AT539045T|2005-07-01|2012-01-15|Firmenich & Cie|PARQUERING COMPONENTS OF THE WOODEN TYPE|

DE102005043188A1|2005-09-09|2007-03-22|Henkel Kgaa|Consumable products with changing odor images|

JP6027718B2|2005-11-30|2016-11-16|エーデンリサーチピーエルシー|Compositions and methods comprising terpenes or terpene mixtures selected from thymol, eugenol, geraniol, citral, and L-carvone|

ZA200802444B|2005-12-07|2009-09-30|Unilever Plc|Improved detergent composition|

WO2007079331A2|2005-12-13|2007-07-12|Richard Paul Bonfiglio|Antibacterial oral rinse formulation for preventing coronary artery disease|

US20070258996A1|2005-12-23|2007-11-08|The Sterilex Corporation|Antimicrobial compositions|

US20070227930A1|2006-03-28|2007-10-04|Bromberg Steven E|Antimicrobial Product Combination|

US7803353B2|2006-03-29|2010-09-28|The Procter & Gamble Company|Oral care compositions having improved consumer aesthetics and taste|

TW200808333A|2006-04-17|2008-02-16|Kaneka Corp|Licorice polyphenol preparation|

FR2900652B1|2006-05-02|2008-08-08|Westrand Internat Sarl|PROCESS FOR TREATING PURIFICATION SLUDGE AND COMPOSITION FOR CARRYING OUT SAID METHOD|

US20070270321A1|2006-05-16|2007-11-22|Barnhart Ronald A|Antimicrobial hand wash formulations|

JP2006307231A|2006-06-12|2006-11-09|Takasago Internatl Corp|Fragrance composition for suppressing iron rust odor|

US20080026974A1|2006-07-27|2008-01-31|Barnhart Ronald A|Antimicrobial hand wash|

US7642227B2|2006-08-07|2010-01-05|Melaleuca, Inc.|Cleansing and disinfecting compositions|

US20100074976A1|2006-08-09|2010-03-25|Dsm Ip Assets B.V.|Novel agents for the treatment of disorders connected to impaired neurotransmission|

US20080045491A1|2006-08-15|2008-02-21|Fitchmun Mark I|Surface sanitizer|

US20080044479A1|2006-08-15|2008-02-21|Stack Kevin C|Antimicrobial sanitizing formulations with skin protection properties|

US7723279B2|2006-08-23|2010-05-25|The Clorox Company|Foamable compositions containing alcohol|

CA2656397A1|2006-09-05|2008-03-13|University Of Manitoba|Antimicrobial coatings|

GB0618657D0|2006-09-21|2006-11-01|Mainsani As|Compositions|

DE102006044942A1|2006-09-22|2008-04-03|Beiersdorf Ag|peeling capsules|

US20080096790A1|2006-10-23|2008-04-24|Quest International Services B.V.|Fragrance compositions|

JP5101081B2|2006-10-31|2012-12-19|日清丸紅飼料株式会社|Feed for prevention and / or treatment of coccidiosis and clostridiasis|

MA29508B1|2006-11-16|2008-06-02|Alloum Abdelkrim Ben|Detergent compositions in the form of microemulsions and their use in the treatment of alopecia|

DE102006056320A1|2006-11-21|2008-05-29|Beiersdorf Ag|Cosmetic formulation with glucosylglycerides and selected perfumes|

US20090099135A1|2007-01-16|2009-04-16|Tyratech, Inc.|Pest control compositions and methods|

GB0707275D0|2007-04-16|2007-05-23|Safemed Ltd|Preservation composition|

US20080253976A1|2007-04-16|2008-10-16|Douglas Craig Scott|Personal Care Compositions Comprising An Antimicrobial Blend of Essential Oils or Constituents Thereof|

CN100488359C|2007-04-26|2009-05-20|江苏省农业科学院|Eugenol micro-emulsion|

US20080274072A1|2007-05-04|2008-11-06|John Manolas|Insect repellants and insecticides|

WO2008157847A1|2007-06-20|2008-12-24|The Trustees Of Columbia University In The City Of New York|Skin and surface disinfectant compositions containing botanicals|

GB0712024D0|2007-06-22|2007-08-01|Givaudan Sa|Compositions|

PL2042041T3|2007-06-29|2015-02-27|Dsm Ip Assets Bv|Use of benzoic acid and thymol, eugenol and piperine in animal feeding|

US8066979B1|2007-07-13|2011-11-29|The United States Of America As Represented By The Secretary Of Agriculture|Attractants and repellents for the tropical root weevil Diaprepes Abbreviatus|

US20090035228A1|2007-08-02|2009-02-05|Shanta Modak|Skin and surface disinfectant compositions containing botanicals|

KR100885511B1|2007-08-22|2009-02-26|이화여자대학교 산학협력단|Composition for growth inhibition of pathogenic microorganisms on meats during distribution using natural additives|

US20090081136A1|2007-09-24|2009-03-26|Deepak Sharma|Compositions Useful For Tooth Whitening|

US20090105195A1|2007-10-17|2009-04-23|O'brien Chris|Composition comprising microbicidal active ingredients|

FR2925334A1|2007-12-21|2009-06-26|Ceva Sante Animale Sa|NEW ANTIBACTERIAL COMPOSITIONS|

WO2009085058A1|2007-12-27|2009-07-09|Guthy-Renker Corporation|Cosmetic cleanser|

WO2009090648A2|2008-01-16|2009-07-23|Technion Research & Development Foundation Ltd.|Use of antimicrobial polymers for re-sensitization of microorganisms upon emergence of resistance to anti-microbial agents|

JP2009196987A|2008-01-23|2009-09-03|Kao Corp|Tooth paste composition for periodontal disease|

RU2370265C1|2008-03-04|2009-10-20|Лев Давидович Раснецов|Gel, possessing anti- inflammatory and antiallergic effect|

CN101590287B|2008-05-28|2012-10-03|3M创新有限公司|Wound filling|

CN101313772B|2008-06-10|2011-08-17|广东广益科技实业有限公司|Bacterium-restraining deoxidization dual-purpose food antistaling agent|

US20100003198A1|2008-07-07|2010-01-07|Patrick John Stolmeier|Antimicrobial Topical and Other Preparations Containing Fluorescent or Illumination Dye and Tracer Agents or Compounds|

JP2010037272A|2008-08-05|2010-02-18|Pola Chem Ind Inc|Cosmetic suitable for massage|

CA2739843C|2008-10-20|2018-01-09|Unilever Plc|Antimicrobial composition comprising thymol and terpineol for disinfecting surfaces|

WO2010077278A1|2008-12-09|2010-07-08|Becton, Dickinson And Company|Dual-chambered drug delivery device for high pressure injections|

US8119588B2|2009-01-21|2012-02-21|Stepan Company|Hard surface cleaner compositions of sulfonated estolides and other derivatives of fatty acids and uses thereof|

KR101195618B1|2009-05-15|2012-10-29|황철수|Composition of Toothpaste for NoSmoking With green laver and Method of Preparing thereof|

CN101601382B|2009-07-20|2012-08-22|中国热带农业科学院环境与植物保护研究所|Thymol mite-killing microemulsion and preparation method thereof|

CN102481242A|2009-08-26|2012-05-30|巴斯夫欧洲公司|Use of 1,3-diols as biocides|

ES2437919T3|2009-09-24|2014-01-15|Unilever Nv|Sanitizing agent comprising eugenol, terpineol and thymol|

BR112012006808A2|2009-10-02|2019-09-24|Yissum Research Development Co Of The Hebrew Univ Of Jerusalem|"sanitizing compositions and method for surface sanitization"|

CN101874531A|2010-04-10|2010-11-03|邯郸市天养生物科技有限公司|Grape seed oil added with tea polyphenol microemulsion and preparation method thereof|

PL2576747T3|2010-05-31|2014-09-30|Unilever Nv|Hard surface treatment composition|

CN102905683B|2010-05-31|2015-09-23|荷兰联合利华有限公司|Composition for processing skin|

KR20120093607A|2011-02-15|2012-08-23|한일제약|Oral liquid-type composition|

CN102229861A|2011-05-16|2011-11-02|安徽华香香料股份有限公司|L-carvone|

JP6203469B2|2011-06-03|2017-09-27|花王株式会社|Dentifrice composition|CA2739843C|2008-10-20|2018-01-09|Unilever Plc|Antimicrobial composition comprising thymol and terpineol for disinfecting surfaces|

ES2437919T3|2009-09-24|2014-01-15|Unilever Nv|Sanitizing agent comprising eugenol, terpineol and thymol|

CN102933191A|2010-05-31|2013-02-13|荷兰联合利华有限公司|Skin treatment composition|

MX2013006435A|2010-12-07|2013-07-03|Unilever Nv|An oral care composition.|

JP5748626B2|2011-09-21|2015-07-15|サンスター株式会社|Oral composition|

BR112014009479B8|2011-11-03|2019-01-29|Unilever Nv|personal cleaning liquid composition and external surface disinfection method|

IN2014MN00929A|2011-11-25|2015-04-17|Unilever Plc|

EA025160B9|2011-12-06|2016-12-30|Юнилевер Н.В.|Antimicrobial composition|

MX364649B|2011-12-06|2019-05-03|Unilever Nv|Antimicrobial composition.|

EP2787825B2|2011-12-06|2021-11-03|Unilever Global IP Limited|Antimicrobial composition|

EA024578B1|2011-12-09|2016-09-30|Юнилевер Н.В.|Antibacterial composition|

MX356280B|2011-12-09|2018-05-22|Unilever Nv|An antimicrobial composition.|

EP2831213B1|2012-03-27|2016-05-18|Unilever N.V.|Soap bar composition|

CN104736687B|2012-09-07|2018-03-02|荷兰联合利华有限公司|Soap composition|

GB201404505D0|2013-09-06|2014-04-30|Mars Inc|Oral anti-parasitic composition|

CN103493832B|2013-09-18|2014-10-22|山东省烟台市农业科学研究院|Efficient complex biological fungicide and application thereof|

US20170027836A1|2014-04-14|2017-02-02|Conopco, Inc., D/B/A Unilever|Personal care composition|

EA030090B1|2014-04-14|2018-06-29|Юнилевер Н.В.|Personal care composition|

US9474701B2|2014-09-09|2016-10-25|Hydromer, Inc.|Antimicrobial soaps containing carvacrol and methods of using same|

CN108289444B|2015-11-27|2021-08-27|联合利华知识产权控股有限公司|Antimicrobial compositions|

MX2018006387A|2015-11-27|2018-09-05|Unilever Nv|An antimicrobial cleansing composition.|

WO2017174296A1|2016-04-04|2017-10-12|Unilever Plc|Fragranced compositions and their use|

WO2017198284A1|2016-05-14|2017-11-23|Symrise Ag|Menthol-containing aroma preparations|

EP3463263B1|2016-05-27|2020-10-21|Unilever N.V.|An antimicrobial cleansing composition|

EP3558002B1|2016-12-20|2022-01-19|Unilever Global IP Limited|An antimicrobial composition comprising oligodynamic metal|

EP3706573A2|2018-03-20|2020-09-16|Firmenich SA|Antimicrobial compositions|

RU2679603C1|2018-05-08|2019-02-12|Акционерное общество "Арнест" |Disinfectant|

CN108690759B|2018-06-28|2021-01-26|青岛市中心医院|Medical cleaning agent and preparation method thereof|

WO2021180909A1|2020-03-13|2021-09-16|Unilever Ip Holdings B.V.|A cleaning composition|

法律状态:
2020-08-25| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|

2020-09-08| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|

2021-01-12| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|

2021-02-17| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 17/02/2021, OBSERVADAS AS CONDICOES LEGAIS. |

2021-07-27| B25A| Requested transfer of rights approved|Owner name: UNILEVER IP HOLDINGS B.V. (NL) |

优先权:

申请号 | 申请日 | 专利标题

IN2220/MUM/2009|2009-09-24|

IN2220MU2009|2009-09-24|

PCT/EP2010/062982|WO2011036048A1|2009-09-24|2010-09-03|Disinfecting agent comprising eugenol, terpineol and thymol|

[返回顶部]